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Biological & Environmental Research
"Chlorobenzene biodegradation under consecutive aerobic-anaerobic conditions", Gerd U. Balcke, Lea P. Turunen, Roland Geyer,
Dirk. F. Wenderoth, Dietmar Schlosser, FEMS Microbiol. Ec. 2004 (49), 109-120
Fibox 3 and PSt3 sensor patches were used to measure the degradation of pollutants. In combination with the total
pressure, O2 partial pressures were obtained upon exposing the oxygen sensor to both the headspace and the liquid phase.
"Full time mothers: daily rhythms in brooding and nonbrooding behaviors of Brachyuran crabs", Nathaly Ruiz-Tagle, Miriam Fernández,
Hans-Otto Pörtner, J. of Exp. Mar. Bio. and Ecology 2002 (276), 31-47
Oxygen availability (% air saturation) in brooding crabs was measured with our oxygen microsensors and Microx TX.
The optical fiber was placed in the center of the embryo mass.
"Micro-optodes in sea ice: a new approach to investigate oxygen dynamics during sea ice formation", Thomas Mock, Gerhard S. Dieckmann, Christian Haas, Andreas Krell, Jean-Louis Tison, Andre
L. Belem, Stathis Papadimitriou, David N. Thomas, Aqu. Microb. Ec. 29: 297-306, 2002
Microx TX with NTH sensors was used to measure oxygen dynamics directly within the microstructure of sea ice by freezing
the sensors into the ice during its formation
"Functional Groups and Activities of Bacteria in a Highly Acidic Volcanic Mountain
Stream and Lake in Patagonia, Argentina", K. Wendt-Potthoff, M. Koschorreck, Microb. Ecol. 43: 92-106, 2002
The authors used a Microx TX to measure the oxygen consumption and oxygen profiles of sediments in the field.
"Lifetime based optodes: an optimal way to monitor Oxygen in the aquatic environment", A.Tengberg, J.Hovdenes, H.Minken, A.Stangelmayer,
G.Holst, I.Klimant, C.Huber, 2002
The authors described the use of oxygen sensor spots in deep sea applications.
"A novel approach to the in situ measurement of oxygen concentrations in the sapwood of woody plants", D. Gansert, M. Burgdorf & R. Losch, Plant, Cell and Envir., 24,
1055-1064, 2001
The authors used Microx TX to measur oxygen concentration in sapwood.
"Natural Communities of Novel Archaea and Bacteria Growing in Cold Sulfurous Springs with a String-of-Pearls-Like Morphology", C. Rudolph, G. Wanner, and R. Huber, App. and
Envir.Microbiolog. Vol 65, No. 5, 2001
The authors used Microx TX to investigate biofilms.
"The cost of being a caring mother: the ignored factor in there production of marine invertebres", M.Fernandez, C.Bock, H.Pörtner, Ecology letters, 3, 487-494, 2000
The authors used Microx TX to study oxygen concentration in crabs.
"Patterns of oxygen supply in embryo masses of brachyuran crabs throughout development: the effect of oxygen availability and chemical cues in determining female brooding
behavior"; Fernández, M.; Pardo, L. M.; Baeza, J. A.; Mar Ecol Prog Ser, Vol. 245, 181-190, 2002
The oxygen microsensor NTH and Microx TX was used to measure oxygen consumption of embryos in the brooding female
crab.
Enzyme & Drug Screening / Microplate Applications
"On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen
sensors", Rahul Ravi Deshpande & Elmar Heinzle, Biotechn. Letters 26, 763-767, 2004
OxoPlate® was used to measure O2 uptake rates of animal cells (Chinese hamster ovary-CHO), application for high-throughput
measurements
"Evaluation of OxoPlate for Real-Time Assessment of Antibacterial Activities", Bernd Hutter, Gernot T. John,
Current Microbiology Vol. 48: 57-61, 2004
OxoPlate® was used to determine MIC. The distinction between bactericidal and bacteriostatic compounds was made simultaneously.
"Rapid Evaluation of Oxygen and Water Permeation through Microplate Sealing Tapes", Hartmut F. Zimmermann, Gernot T. John,
Harald Trauthwein, Uwe Dingerdissen, and Klaus Huthmacher, Biotechnol. Prog., 19: 1061-1063, 2003
OxoPlate® was used to compare different microplate sealings.
"Integrated Optical Sensing of Dissolved Oxygen in Microtiter Plates: A Novel Tool for Microbial Cultivation", Gernot T. John, Ingo Klimant, Christoph Wittmann, Elmar Heinzle, Wiley Periodicals,
Inc. Biotechn. Bioeng. 81: 829-836, 2003
OxoPlate® (prototype) was used to control the oxygen supply of micro-organisms in microplates.
"Entwicklung von innovativen Mikrotiterplattenreaktoren zur Bewertung des Abbaus und der Toxizität neuer Wirkstoffe auf Basis von Mikrosomen und Säugerzellen",
Prof. Dr. Elmar Heinzle, M.Technol. Rahul Ravi Deshpande, Dr. Udo Bock, Dr. Gernot John, Dr. Christian Krause, Dr. Günther
Müller, Dr. Harald Waltenberger, Dr. Ruth Maas, Transkript Sonderband DBU: 66-67, 2003
OxoPlate® was used to investigate toxicity on microsomes and mammalian cells.
"Mikrotiterplatten-Reaktoren mit integrierten pH-Sensoren und Autodisplay in E.coli zur evolutiven Enzymentwicklung", Prof. Dr. Elmar Heinzle, staatl. Gepr. LMChem. Svenja
Weiß, Prof. Dr. Otto Wolfbeis, Dipl.-Chem. Sarina Arain, Prof. Dr. Ingo Klimant, Dr. Christian Krause, Dr. Thomas Räbiger,
Günther Müller, Dr. Harald Waltenberger, Dr. Joachim Jose, Dipl.-Biol. Eva Schultheiss, Transkript Sonderband DBU: 59-62,
2003
HydroPlate® was used to display growth of E. coli.
Food & Beverage
"pH-Sensing 96-well microtitre plates for the characterization of acid production by dairy starter cultures", Gernot T. John,
Detlef Goelling, Ingo Klimant, Holger Schneider and Elmar Heinzle, J. of Dairy Research 70: 327-333, 2003
The HydroPlate® (prototype) was used to measure pH changes of different dairy starter cultures.
Bioprocess Control
"Miniature bioreactors for automated high-throughput bioprocess design (HTBD): Reproducibility of parallel fed-batch cultivations
with Escherichia coli", Puskeiler, R.; Kusterer, A.; John, G. T.; Weuster-Botz, D; Biotechnol. & Appl. Biochem. Immediate
Publication; BA20040197, 2005
Chemical-optical sensors from PreSens were used for measurement and control of the bioprocess in a new multi reactor
vessel. HydroPlate® was used for at-line pH measurement and modified Fibox units were measuring oxygen online.
"Characterization and application of an optical sensor for quantification of dissolved O2 in shake flasks", Christoph Wittmann, Hyung Min Kim,
Gernot John & Elmar Heinzle, Biotechn. Letters 25: 377-380, 2003
Fully autoclavable oxygen sensor spots were integrated into shake flasks. OXY-4 measured the oxygen concentration
online.
"Integrated Optical Sensing of Dissolved Oxygen in Microtites Plates: A Novel Tool for Microbial Cultivation", Gernot
T. John, Ingo Klimant, Christoph Wittmann, Elmar Heinzle, Wiley Periodicals, Inc. Biotechn. Bioeng. 81: 829-836, 2003
OxoPlate® (prototype) was used to control the oxygen supply of micro-organisms in microplates.
"Hochdurchsatz-Bioprozessentwicklung", Prof. Dr.-Ing. Dirk Weuster-Botz, Dipl.-Biotech. Robert Puskeiler, Dr.-Ing. Klaus Kaufmann, Dr. Gernot John, Dr.-Ing. Matthias
Arnold, Transkript Sonderband DBU: 66-67, 2003
In this project, PreSens supplies sensors and opto-electronics to build massively parallel approach toward faster
biotechnology development.
Sensor Principles
"A microoptode array for fine-scale measurement of oxygen distribution", Holst G., Glud R.N., Kühl M., Klimant I., Sensors
and Actuators B, 38-39, 122-129, 1997
"Optical measurement of oxygen and temperature in microscale: strategies and biological
applications", I.Klimant, M.Kühl, R.N.Glud, G.Holst, Sensors and Actuators B, 38-39, 29-37, 1997
"Fiber-optic oxygen microsensors, a new tool in aquatic biology", Klimant I., Meyer V., Kühl M., Limnol. Oceanogr., 40, 1159-1165, 1995
"Fiber Optic Chemical Sensors and Biosensors", Wolfbeis O.S. (Ed.), Vol. 1&2, CRC, Boca Raton, 1991
Vibratome Tissue Slicer
Mounir N. Ghabriel, Chunni Zhu, Gail Hermanis & Gerald Allt Brain Research, 2000, 878:1-2:127-135 mounir.ghabriel@adelaide.edu.au
The other half of the brain was cut into 50 µm sections in the sagittal plane using a Vibratome.
Els D'Hondt, Marianne Eelen, Luc Berghman & Frans Vandesande Brain Research, 2000, 856:1-2:55-67
The brains containing Zamboni's
fixative were embedded in 20% gelatin, transverse vibratome sections (50 µm) were cut and serial sections were collected in
12-well plates containing
Daniel P. Perl, Paul F. Good, Thierry Bussière, John H. Morrison, Joseph M. Erwin & Patrick R. Hof Journal of Chemical Neuroan
Mounir N. Ghabriel, Chunni Zhu, Gail Hermanis & Gerald Allt Brain Research, 2000, 878:1-2:127-135 mounir.ghabriel@adelaide.edu.au
The other half of the brain was cut into 50 µm sections in the sagittal plane using a Vibratome.
Els D'Hondt, Marianne Eelen, Luc Berghman & Frans Vandesande Brain Research, 2000, 856:1-2:55-67
The brains containing Zamboni's fixative were embedded in 20% gelatin, transverse vibratome sections (50 µm) were cut and serial sections were collected in
12-well plates containing
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